Some histological and biochemical evaluation on commercial hair dyes

The use of hair dyes as a means beautification is currently increasing. This study aimed at evaluating the toxicity different commercial on histology skin and biochemical parameters liver Albino rats. was carried out in Pathology Department, University Calabar Teaching Hospital College Medical Sciences, Calabar, between May, 2019 October, 2019. Four colours were obtained from cosmetic store Watt daily market Cross River State. Twenty male rats with average weight 55g used for this study. randomly divided into five (5) groups four (4) each. Group 1 to 4 served test while group 5 control group. Different dye applied topically selected area back 30 days after which, sacrificed using chloroform inhalation procedure. rat harvested heart puncture collect milliliters blood each analysis. Plasma Alkaline phosphatase (ALP) determined Kind King's method. Alanine amino transferase (ALT) Aspartate Amino (AST) by Reitman Frankel Serum protein (TP) Biurette's method bilirubin estimated Powell's Liver tissues processed routine paraffin wax tissue processing histological serum levels ALP, AST, TP, Total (TB) conjugated (CB) all significantly increased when compared (P=0.001). Histological evaluations indicated evidence cellular injury groups. Prolonged caused adverse effects seen